Production and Evaluation of Lutetium-177 Maltolate as a Possible Therapeutic Agent
Authors
Abstract:
This article doesn't have abstract
similar resources
Preparation and quality control of lutetium-177 bleomycin as a possible therapeutic agent
Bleomycins are tumor seeking antibiotics that are widely used in cancer chemotherapy (Fig. 1). It is believed that bleomycin antibiotics interfere with DNA as false nucleotides, assuming the dithiazole moiety acts like a purine base [20]. It has been shown that labeling of bleomycin with bi/trivalent radioisotopes can produce pharmacologically active compounds carrying a diagnostic and/or thera...
full textProduction, Quality Control and Biological Evaluation of 166Ho-PDTMP as a Possible Bone Palliation Agent
Objective(s):In this study, 166Ho-1,2-propylene di-amino tetra(methy1enephosphonicAcid) (166Ho-PDTMP) complex was prepared as a bone palliation agent. Materials and Methods:The complex was successfully prepared using an in-house synthesized EDTMP ligand and 166HoCl3. Ho-166 chloride was obtained by thermal neutron irradiation (1 × 1013 n.cm-2.s-1) of natural Ho(NO3)3 samples followed by radio...
full textProduction, quality control and biological evaluation of 153Sm-TTHMP as a possible bone palliation agent
Introduction: Various bone palliative therapeutic agents have been developed and widely used for bone metastasis such as 153Sm-EDTMP. In this study, production, quality control and biodistribution studies of a newly developed therapeutic compound have been presented followed by imaging studies in wild-type rodents. Methods: 153Sm-TTHMP was prepared starting from 153<...
full textPreparation and quality control of scandium-46 bleomycin as a possible therapeutic agent
Introduction: Due to interesting therapeutic properties of 46Sc and antineoblastic antibiotic, bleomycin (BLM), 46Sc-bleomycin (46Sc-BLM) was developed as a possible therapeutic compound. Methods: In this work, Sc-46 chloride was obtained by thermal neutron flux (4 × 1013 n.cm-2.s-1) of natural metallic scandium sample followed ...
full textPreparation of a 153Sm-5,10,15,20-tetrakis(4-methoxyphenyl) porphyrin complex as a possible therapeutic agent
Introduction: Porphyrins are interesting derivatives with low toxicity, tumor avidity and rapid wash-out suggested as potential radiopharmaceuticals in radiolabeled form. In this work we report, synthesis, radiolabeling, quality control, stability, partition coefficient determination and biodistribution studies of 153Sm-5,10,15,20-tetrakis(4-methoxyphenyl) porphyrin (153Sm-4-MPP) in ...
full textLutetium-177 DOTATATE Production with an Automated Radiopharmaceutical Synthesis System
OBJECTIVES Peptide Receptor Radionuclide Therapy (PRRT) with yttrium-90 ((90)Y) and lutetium-177 ((177)Lu)-labelled SST analogues are now therapy option for patients who have failed to respond to conventional medical therapy. In-house production with automated PRRT synthesis systems have clear advantages over manual methods resulting in increasing use in hospital-based radiopharmacies. We repor...
full textMy Resources
Journal title
volume 33 issue جلد 60
pages 61- 67
publication date 2012-08-22
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023